Athlete Stress Formula:

Phosphatidlyserine Clinical Studies

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Note: This material was excerpted from an article written by Stephen A. Levine, Ph.D.

PS Studies on Stress Response

Phosphatidylserine appears to protect against the stress response and to reduce anxiety, as demonstrated in previous studies. In a 1990 study (Monteleone, P., et al.), the response of BC-PS to physical stress was tested in eight healthy men who underwent three experiments with a bicycle ergometer in a double-blind format.

The physical stress from exercise induced a clear cut increase in plasma epinephrine, norepinephrine, ACTH, cortisol, growth hormone, and prolactin, whereas pretreatment with 50-75 mg of BC-PS significantly blunted the ACTH and cortisol response to the exercise. Plasma growth hormone and prolactin responses to physical stress were not affected by BC-PS.

In 1995, a 2-month treatment study (Gindin, J. et al.) using plant-derived phosphatidylserine (S-PS) showed positive effects on daily functioning, emotional state and self-reported general condition of Alzheimer's disease patients. (See figure 2) In a post-trial consumption survey, nearly half of the participants of the treatment group decided to continue treatment at their own expense, in contrast to none in the placebo group. These results of a short-term treatment which had no negative side effects encourages the use of S-PS with AD patients in order to evaluate on an individual basis possible improvement in patient condition. These results also encourage further investigation into long-term treatment and on larger groups with regard to the patient's AD status, i.e. early, mild and severe AD.

Memory Test Score
Wechsler >68, P<0.03

Gindin J. et al., 1995

In September of 1999, a report summarized results of a study on the kinetics of soy lecithin phosphatidylserine (S-PS) absorption by the body. (See figure 3 chart on bottom right.) The study was carried out in July 1996 with standard soft gelatin capsules containing S-PS supplied by Lipogen Ltd. in Israel. From the study the following was concluded:

• The capsules disintegrated after 30 minutes.
• The PS was well tolerated by the body.
• The basal serum level was reached after 180 minutes from intake.
• No side effects were reported.
• The overall average profile of the PS/PL values attained in the test are shown in the chart below.
• No adverse effects or any discomfort was reported by the participants

PS Levels in Blood Serum

Time (min)

Shinitsky, M, Ph.D., 1196

Soy lecithin phosphatidylserine complex (S-PS) is considered a dietary supplement (lecithin and other phospholipids) and is freely sold as a supplement product (Israel, Europe, USA, etc.).

References

Gindin, J., et al. 1990, Effect of Soy Lecithin Phosphatidylserine (PS) Treatment on Daily Functioning and Self-Reportcd General Condition in Patients with Alzheimer's Disease, The Geriatric Institute of Education and Research Kaplan Medical Centre, Rehovot, and Hadassah Medical School, Hebrew University of Jerusalem, Israel.

Monteleone, P., et al., Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinol, 52:243-249, 1990.

The statements made herein have not been evaluated by the U.S. Food and Drug Administration. The products are not intended to diagnose, treat, cure, or prevent any disease.

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